Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. The June 2004 edition of Breast Cancer Research states that red clover does not cause any oestrogenic increase in breast density, while human and synthetic oestrogen does. Gynecol Endocrinol. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved to be effective in reducing vasomotor symptoms in a number of studies. Phytoestrogens for vasomotor menopausal symptoms. Phytomedicine. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind).  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. 2007;14:153-59. The chemical and biologic profile of a red clover (, Long-term pharmacokinetics of an extract of isoflavones from red clover (. Wang Y, Man Gho W, Chan FL, et al. Numerous studies have shown extracts of red clover to be safe and effective for hot flashes in particular.  Further research is needed to determine the safety and efficacy of this agent. The Early Christians looked at the symbolism of plants and associated the three lobed leaves with the Trinity. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). In postmenopausal women, endometrial status was not adversely affected. It is unclear whether red clover is safe for consumption by women with a history of estrogen-receptor (ER) positive cancer. . Dried red clover flowers have been used in traditional medicine to treat a wide spectrum of ailments, including jaundice, cancer, mastitis, joint disorders, and respiratory conditions (eg, whooping cough, bronchial asthma), and as a sedative. Do not share it with other people. Red Clover herb is a simple to find herb with many uses. 1999;84:895-98. However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. Epub 2011 May 26. 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Hasan Y, Schoenherr D, Martinez AA, et al. 10. Biochanin A (BCA) is a dietary isoflavone present in red clover. All rights reserved. [1,2,3] However, conclusions from systematic reviews have been conflicting: one suggested marginal benefit, whereas another found no evidence of effectiveness. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red clover contains the anticoagulant and blood-thinning compound coumarin. Red clover is used in Turkish folk medicine as expectorant, antiseptic, analgesic properties and as a treatment for rheumatic aches. Red Clover Anti-Cancer Health Benefits. In postmenopausal women, supplementation alleviated vasomotor and menopausal symptoms (18) (25). Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. Although red clover isoflavones show hormonal activity in laboratory experiments, their effects in the human body are less clear. 2005;11:60-65. Also known as: Daidzein, genistein, isoflavone, phytoestrogen, purple clover, trefoil, trifolium, beebread, clovone. Subarachnoid hemorrhage was reported in a 53-year-old woman following use of an herbal supplement that contained red clover, dong quai, and Siberian ginseng, which she took for hot flashes associated with perimenopause. 2008;99:303-10. © 2020 MJH Life Sciences™ and Cancer Network. In a murine model, red clover isoflavones reduced skin aging induced by estrogen deprivation following ovariectomy (5). It has shown a definite limiting effect, however, in the development of benign prostate hyperplasia (BPH), which is a non-cancerous enlargement of the prostate gland. Red clover is a wild plant belonging to the legume family. Red Clover herb is a simple to find herb with many uses. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Firstly, some proponents of its use have suggested that it is effective enough to be used on its own. Supplements containing red clover isoflavones do not adversely affect breast density, skeletal strength or cardiovascular status. A meta-analysis of a standardized extract suggests potential reductions in total cholesterol in peri- and postmenopausal women, but studies were heterogeneous (29). Lukaczer D, Darland G, Tripp M, et al. Patients should consult with their physicians before taking red clover supplements. Red clover is one of the richest sources of isoflavones. Until definitive data are available, patients should avoid use of red clover during radiotherapy for prostate cancer. Cancer: Red clover has been studied for its ability to inhibit the growth of new blood vessels to tumours. In vitro, red clover extract acts as an estrogen agonist and stimulates proliferation of estrogen receptor–positive breast cancer cells. Red clover is a perennial herb traditionally used to treat skin conditions such as... ALSO KNOWN AS: . In addition, here is an article from the Mayo Clinic mentioning how isoflavones in food such as soy are not sufficient to cause breast cancer, and in fact a lifelong diet including such foods actually reduces breast cancer: Read the article from the Mayo Clinic (Red clover is an herb, which is considered a food). Here are a few of the most common uses. The controversy concerning the use of red clover for the treatment of cancer is twofold. Because red clover contains isoflavones that mimic the effects of the hormone estrogen once they enter the body, the safety of RC in patients with breast or endometrial cancer remains controversial. Red clover is also a source of many valuable nutrients including calcium, chromium, magnesium, niacin, phosphorus, potassium, thiamine, and vitamin C. In one case, the issue resolved after supplement discontinuation. This not only helps to reduce growth of tumours but can also work to shrink them. Clinical relevance has yet to be determined.Cytochrome P450 enzymes: Preclinical studies suggest red clover can inhibit CYP 1A2, 2C8, 2C9, 2C19, 2D6, and 3A4, and may interact with substances metabolized by these enzymes (17) (28). Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. The loss of elasticity can contribute to increased blood pressure, causing the heart to work harder. 2002;42:187-93. Red Clover Uses. Data from clinical trials suggest that supplementation with red clover isoflavones helps relieve menopausal symptoms. The red clover plant actually belongs to the legume plant family (just like peanuts and beans), which is why animals often graze on it in the wild. Dietary isoflavone intake also improved arterial compliance, an index of large artery elasticity which is an important cardiovascular risk factor (12). Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Red Clover tea, made from the red blossoms, was an old remedy for winter colds. Altern Ther Health Med. Well, this can be dangerous, both for your breast and your liver! Red clover is a wild plant belonging to the legume family. If your symptoms do not improve or if they become worse, contact your doctor or pharmacist as soon as possible. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. Red Clover Benefits: as a Phytoestrogen. Red Clover is not suitable for patients with hormone diseases such as breast, uterine, ovarian cancer or endometriosis. Red clover is used in the treatment of skin complaints (especially eczema and psoriasis), cancers of the breast, ovaries and lymphatic system, chronic degenerative diseases, gout, whooping cough and dry coughs. 1. Among classic herbalists, red clover is known as one of the world’s oldest and most common natural herbal supports for the treatment for all varieties of cancer — anywhere in the body. Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. After postoperative re-hemorrhage, an intraoperative thromboelastogram confirmed that antiplatelet effects were more likely than coumarin toxicity. Two: This is often used for children that have a persistent, bad cough. Clinical relevance has yet to be determined.Methotrexate: Red clover was reported to cause toxicity, resulting in severe vomiting and epigastric pain, when used along with methotrexate injections (19). Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. The British Journal of Nutrition discovered that red clover … Avoid large amounts and use with caution. One study in menopausal women suggests that red clover extract can improve elasticity of major arteries. It turns out that the isoflavones in red clover may possess antitumor activity in the test tube. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. and anti-osteoporotic effects, as well as for their ability to relieve menopausal symptoms. Br J Nutr. The flower is also used for inflammatory conditions associated with arthritis and gout. Anticoagulants / Antiplatelets: Preclinical studies suggest red clover may increase their effects (20). Subdural hematoma: In a 65-year-old woman with no other risk factors for bleeding except long-term use of red clover supplements for postmenopausal symptoms. Red clover may also block enzymes thought to contribute to prostate cancer in men. -Barrie Cassileth, PhD. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. The phytoestrogenic properties of the isoflavones in red clover are why it is not recommended for use by women who’ve been diagnosed with breast cancer, without first discussing it with their physician. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Do not take red clover if on a blood thinner, or when using melilot an herb that enhances bleeding. Preclinical studies suggest red clover extract may act as an estrogen agonist and stimulate proliferation of ER-positive breast cancer cells (1).  In other studies, red clover isoflavones reduced bone loss and improved arterial compliance (the latter is an index of the elasticity of large arteries, an important cardiovascular risk factor). Was this article helpful? Red clover is a perennial herb traditionally used to treat skin disorders such as psoriasis and eczema, whooping cough, and mastitis. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Red Clover Kills Prostate Cancer Cells By Michael A. Smith, MD More than 238,000 men will be diagnosed with prostate cancer in the United States, and nearly 30,000 will die from it. While historically the RC plant has been taken in the form of tea and tinctures, today it’s often used to make extracts, such as the products … Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Her symptoms resolved after discontinuation of the supplement.. Whilst there have been some very preliminary scientific studies to support the anti-cancer properties of Red Clover the evidence throughout the ages, like virtually all of our herbal lore, has been gathered through experience and observation. Red clover, although it does not cause cancer, is not to be played with! Red clover has been used for hundreds of years as a natural herbal remedy to treat many different diseases, including joint problems, respiratory illnesses, muscular aches and pains (particularly mastitis), inflammation of the skin and other soft tissue, and many types of cancer. Those with hormone-sensitive conditions, such as breast cancer, ovarian cancer, or endometriosis,... Drug interactions. More studies are needed. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. 2007(4):CD001395. In a trial involving osteopenic postmenopausal women, a red clover extract rich in isoflavones, aglycones, and probiotics attenuated bone mineral density loss caused by estrogen deficiency and improved bone turnover (26). Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. Studies on whether red clover may help reduce menopausal symptoms are mixed, and additional study is needed to confirm positive effects and safety with long-term use. Nourishing food herbs like Red Clover have been used for thousands of years with no indication the plant contributed to estrogen dominant conditions or estrogen-sensitive cancers. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … 2000;66:1281-91. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. The formula was developed after his grandfather observed what sick horses grazed on to restore their health. Case reports However, compared to estrogen, which has relative high binding affinity for the ER-α and ER-β, isoflavones demonstrate up to ~1600 times lower affinity for ER-α meaning they should not increase the risk of cancer. Patients with hormone-sensitive cancers should avoid red clover because it has estrogenic activity, Red clover may increase effects of anticoagulants and antiplatelet drugs, Red clover causes toxic effects when used with methotrexate, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … Otherwise there is no stand All rights reserved. Historically, red clover was used for asthma, whooping cough, cancer, and gout. Coon JT, Pittler MH, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. But as you can see hormone support for her helps in treating cancer such as breast cancer if used before actually getting the cancer. Red clover is a wild plant belonging to the legume family. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones.Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. Red clover leaf extract may decrease the effectiveness of your birth control pill. Neurocrit Care. However, it is not known if red clover can protect against the development of heart disease, and this will also require more clinical trials. Phytoestrogens for vasomotor menopausal symptoms. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. Symptoms resolved after supplement discontinuation (16). Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Genistein, an active component of red clover is believed to be one of 4 herbs responsible for … Friedman JA, Taylor SA, McDermott W, Alikhani P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Formononetin, an isoflavone, induced apoptosis in human breast cancer cells by activating the Ras-p38 mitogen-activated protein kinase in ER-positive breast cancer cells (23). The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. MSK is revolutionizing the way cancer is understood, diagnosed, and treated. Potential interactions between alternative therapies and warfarin. Bleeding around the brain or skull: Related to herbal supplements containing red clover used for menopausal symptoms. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Please keep in mind that clinical studies have shown that some phytoestrogens have anti-cancer properties. C'est pour cette raison que de […] Secondly, some of the types of cancer for which red clover has been traditionally used include cancers of the breast, uterus, ovaries, and prostate, for which estrogenic activity is considered to be contraindicated. Also, red clover may increase the effects of anticoagulants and antiplatelet drugs. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. An increase in density is associated with a higher risk of breast cancer, inferring that taking red clover could prove to … Isoflavones have generated considerable interest in the last decade because of their possible cancer-preventive, cardioprotective. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Potential uses: Red clover is used to treat menopausal symptoms and breast pain. Patients taking hormonal contraceptives should not use clover, as this may reduce the effect of contraception. Comme vous le savez probablement, ces thérapies médicamenteuses font l'objet de discussions multiples aujourd'hui, car elles sont associées à une augmentation du risque de cancer du sein. There was no further bleeding after the patient was subsequently treated with tranexamic acid and platelet transfusions (6). The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Subarachnoid hemorrhage: In a 53-year-old woman following use of an herbal supplement containing red clover, dong quai, and Siberian ginseng for perimenopausal hot flashes. Si vous êtes en période de ménopause, vous avez peut-être envisagé les thérapies hormonales afin de réduire les symptômes les plus gênants. Red clover contains substances called isoflavones. Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. 2007;7:76-80. Red clover has similar effects to estrogen and could complicate these conditions and interfere with treatment. Isoflavones are effective in treating several conditions such as hot flashes, cardivascular health and osteporosis. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood.